Monday April 26, 2021
8:45AM
Conference Welcome
9:00AM-9:45AM
Keynote Talk: Getting up close and personal with precision medicine: how computational biology is rapidly advancing single-subject studies (S3)
Presenter: Yves A. Lussier, MD
9:45AM
Break
10:00AM-11:30AM
Breakout Session 1
Terminologies and Standards in Big Data Analysis
Breakout Session 2
Personalize Drug Safety to Prevent Drug-Induced Liver Injury
Breakout Session 3
SEQing better medicines: the emerging use of genomic technology in the therapeutic development
11:30AM-12:30PM
Young Scientist Award Sessions: Students
12:30PM-1:30PM
Lunch Break
1:30PM-2:15PM
Keynote Talk: Formula 1: Curated Data + Rigorous Validation = Predictive Models of Chemical Bioactivity and Safety
Presenter: Alexander Tropsha, PhD
2:15PM
Break
2:30PM-4:00PM
Breakout Session 4
Application of Machine Learning in Components of Predictive Public Health
Breakout Session 5
Cancer Informatics
Breakout Session 6
Model-Informed Drug Discovery and Development: Opportunities and Challenges
4:00PM-5:00PM
Business Meeting
Tuesday April 27, 2021
8:45AM
Conference Announcements
9:00AM-9:45AM
Keynote Talk: FAIR data for humans and machines
Presenter: Susanna-Assunta Sansone, PhD
9:45AM
Break
10:00AM-11:30AM
Breakout Session 7
Trusted Reproducible Applications supporting Data Integrity and Evidence Acceptance in Healthcare
Breakout Session 8
Optimizing computer-aided drug discovery and development for swifter response to public outbreaks
Breakout Session 9
Omics-Scale Assays for Chemical Safety and Drug Discovery
11:30AM-12:30PM
Young Scientist Award Sessions: Postdoctoral Fellows
12:30PM-1:30PM
Lunch Break
1:30PM-2:15PM
Keynote Talk: The molecular impact of a year in space and plans for Mars
Presenter: Christopher Mason, PhD
2:15PM
Break
2:30PM-4:00PM
Breakout Session 10
Network biology and medicine
Breakout Session 11
Animal Microbiome Consortial (AMC): Best Practices and Opportunities for Advancement
Breakout Session 12
Artifcial Intelligence (AI) Shakes Up Drug Discovery
4:00PM-5:30PM
MCBIOS Board Meeting
Wednesday April 28, 2021
9:00AM-12:30PM
MCBIOS-MAQC Poster Session 1 (and 4, if needed)
Break & Poster Discussion
MCBIOS-MAQC Poster Session 2 (and 5, if needed)
Break & Poster Discussion
MCBIOS-MAQC Poster Session 3 (and 6, if needed)
Break & Poster Discussion
12:30PM-1:00PM
Lunch Break
1:00PM-2:45PM
Stat Wars on Reproducibility - Re-understanding P-Values and Artificial Intelligence Methods in the context of Reproducibility
Chair: Weida Tong, NCTR/FDA, USA
Fall of P-Values and Machine Learning: A perspective from the FDA-led MAQC projects, Leming Shi, Fudan University, Shanghai, China
Reproducibility Strikes Back – Reproducibility challenges in an era of massive data, Wendell Jones, Q2 Solutions|EA Genomics, USA
Return of P-Values: Statistics Wars and P-values for Scientists, Russ Wolfinger, SAS institute, USA
Attack of Artificial Intelligence: Reproducibility in AI – a recommendation, Benjamin Haibe-Kains, Princess Margaret Cancer Centre, University Health Network; University of Toronto, Toronto, Canada
A New Hope: AI and FDA, Shraddha Thakkar, NCTR/FDA, USA
The Last Statistician: Data integrity and QC towards improved reproducibility, Rebecca Kusko, Immuneering Corp, USA
Revenge of Reproducibility: Q/A with all the speakers
Workshop Description: Reproducibility is a fundamental hallmark of good science, essential for toxicological research as well as regulatory applications. However, what is reproducibility and how it impacts the toxicological research? Today, we are often no longer experimentally testing only one potentially variable factor; instead it is common to examine thousands or millions of factors simultaneously such as toxicogenomics. How reproducibility is manifested in these new data streams which are crucial to 21st century toxicology? Moreover, the recent debate over the utility of the p-value in framing experimental results in published literature has contributed to the already confused perception and interpretation for “reproducibility”. Scientists typically have several misperceptions of p-values, including an intuition that they are reproducible in nearly all cases when experiments are well-controlled and well-executed, when this is not actually true. The FDA-led MicroArray Quality Control (MAQC) Consortium has been set up to address critical questions related to the reproducibility of modern science. This workshop will provide the current thinking and on-going research in this critical area with an emphasis on genomics application for underlying mechanisms of disease and health and biomarkers.
2:45PM
Break
3:00PM-3:25PM
Keynote Speaker – Dr. William Slikker, Director FDA-NCTR
3:25PM
Special Session I on SEQC2 WG#1 (Whole Genome/Transcriptome)
3:25PM-3:55PM
Session 3 – SEQC2 WG#1
Dr. Wenming Xiao, FDA-CDRH
Towards best practice in cancer mutation detection with whole-genome and whole-exome sequencing
3:55PM-4:25PM
Session 3 – SEQC2 WG#1
Dr. Li Tai Fang, Roche
Establishing reference samples for detection of somatic mutations and germline variants with NGS technologies
4:25PM-4:55PM
Session 3 – SEQC2 WG#1
Dr. Charles Wang, LLU
Towards Best Practice in Single-cell Sequencing: A Comprehensive Multi-Center Cross-platform Benchmarking Study of Single-cell RNA Sequencing Using Reference Samples
4:55PM-5:05PM
Q&A
5:05PM
Awards Presentations
Closing Announcements and Adjourn
Thursday April 29, 2021
8:30AM
Announcements
8:45AM
Special Remarks (Q2 CSO/ EA GM / Dr. Weida Tong)
9:00AM-9:30AM
Invited Speaker – Dr. Elena Helman, Bioinformatics Director, Guardant Health
9:30AM-10:00AM
Invited Speaker - Dr. Shirley Wang, Harvard University and REPEAT Director
10:00AM-10:20AM
Invited Speaker - Dr. Kelly Rose, Burroughs Wellcome Fund
10:20AM
Break
10:50AM
Sessions II-A and II-B – SEQC2 and Invited/Contributed Papers
10:50AM-12:20PM
II-A
Track A – SEQC2 Track
SEQC2 WG #2 (3 papers – Reference Material, Oncopanel testing, Liquid Biopsy testing)
II-B
Track B – Invited or Contributed Papers
12:20PM-12:30PM
Q&A
12:30PM
Lunch Break
1:00M-1:30PM
Session III Keynote – Dr. Joel Parker, Assoc. Professor UNC-CH and Bioinformatics Director Lineberger Comprehensive Cancer Center
1:30PM
Sessions III-A and III-B
1:30PM-3:00PM
III-A
Track A – SEQC2 Track
SEQC2 WG #2 (3 papers – Synthetic reference material, FFPE impacts and related factors
III-B
Track B – Invited or Contributed Papers
3:00PM-3:10PM
Q&A
3:15PM
Break
4:00PM
Sessions IV-A and IV-B
4:00PM-5:15PM
IV-A
Track A – SEQC2 Track
SEQC2: WG #2 & #3 (3 papers – including Targeted RNA-based variant detection ,NGS and HLA, SEQC2 WG#3 overview)
IV-B
Track B – Invited or Contributed Papers
5:15PM-5:25PM
Q&A
5:30PM
Adjourn
Friday April 30, 2021
8:30AM
Initial Remarks, Announcements, Awards
8:45AM-9:20AM
Session V – Friday morning Keynote – Dr. Rebecca Doerge, Dean of the Mellon College of Science, CMU
9:20AM
Sessions V-A and V-B
9:20AM-10:30AM
V-A
Track A – SEQC2 Track
SEQC2 WG #7: The Epigenome Quality Control (EpiQC) Project, Multiplatform Assessment of Metagenomics
V-B
Track B – Invited or Contributed Papers
10:30AM-10:35AM
Q&A
10:35AM
Break
11:00AM
Sessions VI-A and VI-B
11:00AM-12:30PM
VI-A
Track A – SEQC2 Track
SEQC2 Special topics including Structural Variant detection
VI-B
Track B – Invited or Contributed Papers
12:30PM-12:40PM
Q&A
12:45PM
Break
1:30PM
Sessions VII-A andVII-B
1:30PM-3:00PM
VII-A
Track A – SEQC2 Track
SEQC2 Topics TBD
VII-B
Track B – Invited or Contributed Papers
3:00PM-3:10PM
Q&A
3:15PM
Plans for 5th Annual Meeting of MAQC Society 2022, at SAS Institute, Cary, NC
5:30PM
Adjourn