Agenda

Monday April 26, 2021

8:45AM

Conference Welcome

9:00AM-9:45AM

Keynote Talk: Getting up close and personal with precision medicine: how computational biology is rapidly advancing single-subject studies (S3)

Presenter: Yves A. Lussier, MD

9:45AM

Break

10:00AM-11:30AM

Breakout Session 1

Terminologies and Standards in Big Data Analysis

Breakout Session 2

Personalize Drug Safety to Prevent Drug-Induced Liver Injury

Breakout Session 3

SEQing better medicines: the emerging use of genomic technology in the therapeutic development

11:30AM-12:30PM

Young Scientist Award Sessions: Students

12:30PM-1:30PM

Lunch Break

1:30PM-2:15PM

Keynote Talk: Formula 1: Curated Data + Rigorous Validation = Predictive Models of Chemical Bioactivity and Safety

Presenter: Alexander Tropsha, PhD

2:15PM

Break

2:30PM-4:00PM

Breakout Session 4

Application of Machine Learning in Components of Predictive Public Health

Breakout Session 5

Cancer Informatics

Breakout Session 6

Model-Informed Drug Discovery and Development: Opportunities and Challenges

4:00PM-5:00PM

Business Meeting

Tuesday April 27, 2021

8:45AM

Conference Announcements

9:00AM-9:45AM

Keynote Talk: FAIR data for humans and machines

Presenter: Susanna-Assunta Sansone, PhD

9:45AM

Break

10:00AM-11:30AM

Breakout Session 7

Trusted Reproducible Applications supporting Data Integrity and Evidence Acceptance in Healthcare

Breakout Session 8

Optimizing computer-aided drug discovery and development for swifter response to public outbreaks

Breakout Session 9

Omics-Scale Assays for Chemical Safety and Drug Discovery

11:30AM-12:30PM

Young Scientist Award Sessions: Postdoctoral Fellows

12:30PM-1:30PM

Lunch Break

1:30PM-2:15PM

Keynote Talk: The molecular impact of a year in space and plans for Mars

Presenter: Christopher Mason, PhD

2:15PM

Break

2:30PM-4:00PM

Breakout Session 10

Network biology and medicine

Breakout Session 11

Animal Microbiome Consortial (AMC): Best Practices and Opportunities for Advancement

Breakout Session 12

Artifcial Intelligence (AI) Shakes Up Drug Discovery

4:00PM-5:30PM

MCBIOS Board Meeting

Wednesday April 28, 2021

9:00AM-12:30PM

MCBIOS-MAQC Poster Session 1 (and 4, if needed)

Break & Poster Discussion

MCBIOS-MAQC Poster Session 2 (and 5, if needed)

Break & Poster Discussion

MCBIOS-MAQC Poster Session 3 (and 6, if needed)

Break & Poster Discussion

12:30PM-1:00PM

Lunch Break

1:00PM-2:45PM

Stat Wars on Reproducibility - Re-understanding P-Values and Artificial Intelligence Methods in the context of Reproducibility

Chair: Weida Tong, NCTR/FDA, USA

  1. Fall of P-Values and Machine Learning: A perspective from the FDA-led MAQC projects, Leming Shi, Fudan University, Shanghai, China

  2. Reproducibility Strikes Back – Reproducibility challenges in an era of massive data, Wendell Jones, Q2 Solutions|EA Genomics, USA

  3. Return of P-Values: Statistics Wars and P-values for Scientists, Russ Wolfinger, SAS institute, USA

  4. Attack of Artificial Intelligence: Reproducibility in AI – a recommendation, Benjamin Haibe-Kains, Princess Margaret Cancer Centre, University Health Network; University of Toronto, Toronto, Canada

  5. A New Hope: AI and FDA, Shraddha Thakkar, NCTR/FDA, USA

  6. The Last Statistician: Data integrity and QC towards improved reproducibility, Rebecca Kusko, Immuneering Corp, USA

  7. Revenge of Reproducibility: Q/A with all the speakers

Workshop Description: Reproducibility is a fundamental hallmark of good science, essential for toxicological research as well as regulatory applications. However, what is reproducibility and how it impacts the toxicological research? Today, we are often no longer experimentally testing only one potentially variable factor; instead it is common to examine thousands or millions of factors simultaneously such as toxicogenomics. How reproducibility is manifested in these new data streams which are crucial to 21st century toxicology? Moreover, the recent debate over the utility of the p-value in framing experimental results in published literature has contributed to the already confused perception and interpretation for “reproducibility”. Scientists typically have several misperceptions of p-values, including an intuition that they are reproducible in nearly all cases when experiments are well-controlled and well-executed, when this is not actually true. The FDA-led MicroArray Quality Control (MAQC) Consortium has been set up to address critical questions related to the reproducibility of modern science. This workshop will provide the current thinking and on-going research in this critical area with an emphasis on genomics application for underlying mechanisms of disease and health and biomarkers.

2:45PM

Break

3:00PM-3:25PM

Keynote Speaker – Dr. William Slikker, Director FDA-NCTR

3:25PM

Special Session I on SEQC2 WG#1 (Whole Genome/Transcriptome)

3:25PM-3:55PM

Session 3 – SEQC2 WG#1

Dr. Wenming Xiao, FDA-CDRH
Towards best practice in cancer mutation detection with whole-genome and whole-exome sequencing

3:55PM-4:25PM

Session 3 – SEQC2 WG#1

Dr. Li Tai Fang, Roche
Establishing reference samples for detection of somatic mutations and germline variants with NGS technologies

4:25PM-4:55PM

Session 3 – SEQC2 WG#1

Dr. Charles Wang, LLU
Towards Best Practice in Single-cell Sequencing: A Comprehensive Multi-Center Cross-platform Benchmarking Study of Single-cell RNA Sequencing Using Reference Samples

4:55PM-5:05PM

Q&A

5:05PM

Awards Presentations
Closing Announcements and Adjourn

Thursday April 29, 2021

8:30AM

Announcements

8:45AM

Special Remarks (Q2 CSO/ EA GM / Dr. Weida Tong)

9:00AM-9:30AM

Invited Speaker – Dr. Elena Helman, Bioinformatics Director, Guardant Health

9:30AM-10:00AM

Invited Speaker - Dr. Shirley Wang, Harvard University and REPEAT Director

10:00AM-10:20AM

Invited Speaker - Dr. Kelly Rose, Burroughs Wellcome Fund

10:20AM

Break

10:50AM

Sessions II-A and II-B – SEQC2 and Invited/Contributed Papers

10:50AM-12:20PM

II-A

Track A – SEQC2 Track
SEQC2 WG #2 (3 papers – Reference Material, Oncopanel testing, Liquid Biopsy testing)

II-B

Track B – Invited or Contributed Papers

12:20PM-12:30PM

Q&A

12:30PM

Lunch Break

1:00M-1:30PM

Session III Keynote – Dr. Joel Parker, Assoc. Professor UNC-CH and Bioinformatics Director Lineberger Comprehensive Cancer Center

1:30PM

Sessions III-A and III-B

1:30PM-3:00PM

III-A

Track A – SEQC2 Track
SEQC2 WG #2 (3 papers – Synthetic reference material, FFPE impacts and related factors

III-B

Track B – Invited or Contributed Papers

3:00PM-3:10PM

Q&A

3:15PM

Break

4:00PM

Sessions IV-A and IV-B

4:00PM-5:15PM

IV-A

Track A – SEQC2 Track
SEQC2: WG #2 & #3 (3 papers – including Targeted RNA-based variant detection ,NGS and HLA, SEQC2 WG#3 overview)

IV-B

Track B – Invited or Contributed Papers

5:15PM-5:25PM

Q&A

5:30PM

Adjourn

Friday April 30, 2021

8:30AM

Initial Remarks, Announcements, Awards

8:45AM-9:20AM

Session V – Friday morning Keynote – Dr. Rebecca Doerge, Dean of the Mellon College of Science, CMU

9:20AM

Sessions V-A and V-B

9:20AM-10:30AM

V-A

Track A – SEQC2 Track
SEQC2 WG #7: The Epigenome Quality Control (EpiQC) Project, Multiplatform Assessment of Metagenomics

V-B

Track B – Invited or Contributed Papers

10:30AM-10:35AM

Q&A

10:35AM

Break

11:00AM

Sessions VI-A and VI-B

11:00AM-12:30PM

VI-A

Track A – SEQC2 Track
SEQC2 Special topics including Structural Variant detection

VI-B

Track B – Invited or Contributed Papers

12:30PM-12:40PM

Q&A

12:45PM

Break

1:30PM

Sessions VII-A andVII-B

1:30PM-3:00PM

VII-A

Track A – SEQC2 Track
SEQC2 Topics TBD

VII-B

Track B – Invited or Contributed Papers

3:00PM-3:10PM

Q&A

3:15PM

Plans for 5th Annual Meeting of MAQC Society 2022, at SAS Institute, Cary, NC

5:30PM

Adjourn